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This research aims to investigate the cytogenetic and biochemical impacts of moxifloxacin on Allium cepa.

July 15, 2026Scientific ReportsOpen Access

Insights into the toxic effects of moxifloxacin in Allium cepa through multiparametric experimental and in silico analyses

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Experimental and in silico analyses reveal moxifloxacin's toxicity in Allium cepa, suggesting significant ecological implications.

This research aims to investigate the cytogenetic and biochemical impacts of moxifloxacin on Allium cepa.
Onion roots were exposed to moxifloxacin at concentrations of 15, 29, and 57 µg/L.
Genotoxicity was assessed through mitotic index, micronucleus frequency, chromosomal aberrations, and the Comet assay.
Biochemical analyses measured oxidative stress markers like MDA, SOD, and CAT.
Mitotic activity reduced by 21% in the highest dose group, with significant increases in micronucleus and chromosomal aberration frequencies.
DNA damage showed a tail DNA percentage increase from 2.60% to 60.9%, and a tail moment increase from 0.05 to 15.82.
Malondialdehyde levels increased by 2.06-fold, while SOD and CAT activities increased by 1.84-fold and 3.23-fold, respectively.

Kuloğlu et al. (2026) studied this question.

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July 15, 2026Scientific ReportsOpen Access

View Full Paper

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Authors

Experimental and in silico analyses reveal moxifloxacin's toxicity in Allium cepa, suggesting significant ecological implications.

This research aims to investigate the cytogenetic and biochemical impacts of moxifloxacin on Allium cepa.
Onion roots were exposed to moxifloxacin at concentrations of 15, 29, and 57 µg/L.
Genotoxicity was assessed through mitotic index, micronucleus frequency, chromosomal aberrations, and the Comet assay.
Biochemical analyses measured oxidative stress markers like MDA, SOD, and CAT.
Mitotic activity reduced by 21% in the highest dose group, with significant increases in micronucleus and chromosomal aberration frequencies.
DNA damage showed a tail DNA percentage increase from 2.60% to 60.9%, and a tail moment increase from 0.05 to 15.82.
Malondialdehyde levels increased by 2.06-fold, while SOD and CAT activities increased by 1.84-fold and 3.23-fold, respectively.

Kuloğlu et al. (2026) studied this question.

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