369P Family history of cancer (FHC) in non-small cell lung cancer (NSCLC): A cross-sectional-prospective study to guide germline referral

Q: What does this research mean for the field?

High opportunistic CT usage is not causally linked to increased early-stage lung cancer detection or resections, questioning the efficacy of non-targeted screening. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

Fabrizio Citarella; F.M. Venanzi; K. Takada; Pierfilippo Crucitti; Carla Lintas; M. Fiorenti; E.C. Mingo; G. La Cava; M. Russano; Francesco Pantano; B. Vincenzi; G. Tonini; T. Vavala; E. Milanesi; Sara Oresti; A. Delmonte; R. Ferrara; M. Di Maio; Fiorella Gurrieri; A. Cortellini

doi:10.1016/j.esmoop.2026.106682

Key Points

The study aims to explore the role of family history of cancer in the context of non-small cell lung cancer and its implications for germline referral.
Cross-sectional-prospective design
Assessment of CT scan usage and early-stage lung cancer detections
Examination of geographic and smoking-related variations
High usage of CT scans varies geographically and is linked to smoking habits.
No significant link found between CT scans and early-stage lung cancer detection or resections.
Rising scans parallel early detections but do not establish causation, raising questions about screening efficacy.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Cross-sectional study investigates early-stage detection in non-small cell lung cancer, suggesting caution in screening practices.

Abstract

Conclusions: High CT usage shows geographic/smoking-linked variation but no link to early-stage lung cancer detection or resections.Rising scans parallel early detections without causation, questioning opportunistic screening efficacy outside targeted programs.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Citarella et al. (2026) studied this question.

synapsesocial.com/papers/69be34d16e48c4981c672e6d https://doi.org/10.1016/j.esmoop.2026.106682

View Full Paper

Ask AI

Bookmark

Share

369P Family history of cancer (FHC) in non-small cell lung cancer (NSCLC): A cross-sectional-prospective study to guide germline referral

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

369P Family history of cancer (FHC) in non-small cell lung cancer (NSCLC): A cross-sectional-prospective study to guide germline referral

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading