372P A blood-based multimarker model for non-invasive detection of non-small cell lung cancer

March 17, 2026ESMO OpenOpen Access

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Key Points

The aim is to develop a blood-based multimarker model for the non-invasive detection of non-small cell lung cancer (NSCLC).
Conducted an observational phase of the study.
Calculated FHC ratios across various degrees.
Assessed total FHC scores and percentile thresholds.
Evaluated patients for germline mutation testing based on FHC utility.
90th percentile threshold was 0.89, indicating strong performance.
Total FHC score had a mean of 0.43 and median of 0.40.
9.8% of patients met the 90th percentile threshold for inclusion.
24.7% of patients met the 75th percentile threshold for inclusion.

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Observational phase demonstrates potential for non-invasive detection of non-small cell lung cancer, suggesting new diagnostic pathways.

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Zhilenkova et al. (2026) studied this question.

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