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March 21, 2026Journal of Craniovertebral Junction and SpineOpen Access

Depression and psychotic disorders worsen perioperative outcomes and increase resource utilization after multilevel lumbar fusion: Implications for screening and perioperative care

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Authors

LMLeonidas E. MastrokostasPMPaul G. MastrokostasLSLuke B. Schwartz

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Overview

Retrospective cohort study shows depression and psychotic disorders worsen outcomes in lumbar fusion, indicating need for screening.

Key Points

  • This study aims to quantify the prevalence of depression and psychotic disorders and evaluate their associations with perioperative outcomes after lumbar fusion surgery.
  • Retrospective cohort analysis using National Inpatient Sample data from 2016 to 2022.
  • Identified depression and psychotic disorders via Elixhauser-derived indicators.
  • Evaluated outcomes including complications, length of stay, and costs using statistical methods.
  • 18.6% of admissions had depression and 2.5% had psychoses.
  • Depression linked to increased odds of cardiovascular complications (OR: 1.25) and mechanical complications (OR: 1.29).
  • Psychoses linked to higher odds of cardiovascular (OR: 1.26) and mechanical complications (OR: 1.59).
  • Mean length of stay increased significantly with the presence of these disorders (4.3 to 5.1 days).
  • Hospitalization costs also increased, with costs rising from $53,200 to $57,900.

Cite This Study

Mastrokostas et al. (2026) studied this question.

synapsesocial.com/papers/69be36e36e48c4981c67612ehttps://doi.org/10.4103/jcvjs.jcvjs_214_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Depression and psychotic disorders elevate inpatient burden after posterior cervical decompression and fusion: Prioritizing screening and targeted discharge planning2026
  2. 2The Impact of Major Depressive Disorder on Somatic and Psychiatric Outcomes Following Elective Single-Level Lumbar Fusion: A Propensity Score-Matched Analysis2026
  3. 3788 Impact of Preoperative Mental Health State on Perioperative Surgical Outcomes After Lumbar Spine Fusions: An Analysis of the National Inpatient Sample (2009-2020)2024
  4. 4Positive Preprocedure Depression Screening Is Associated With Worse Outcomes After Single-Level Posterior-Only Lumbar Fusion: A Retrospective Cohort Analysis2025 · 1 citations
  5. 5New-Onset Psychiatric Disorders After Lumbar Fusion: Predictors, Timing, and Risk Stratification2025