This method synthesizes spiroindoline-pyranocarbazole derivatives, suggesting a versatile approach for novel compounds.
A new method has been developed for the synthesis of spiroindoline-fused pyrano[3,2-c] and pyrano[3,2-a]carbazole derivatives via a three-component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isatins, and aryl enaminyl ketones. The transformation is proposed to occur through a sequence involving Knoevenagel condensation, Michael addition, ortho-cyclization, elimination, and isomerization. This protocol offers such advantages as ease of product isolation, good functional group tolerance, and high yields.
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Padmaja et al. (2026) studied this question.
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