Polymer-lipid hybrid nanoparticles co-encapsulating fucoxanthin and carbon dots for targeted anti-inflammatory therapy in Alzheimer´s disease

J. Horacio Silvestre-Martínez; Lorna G. Yañez-Algandar; Karina del Carmen Lugo-Ibarra; Ana B. Castro-Ceseña

doi:10.1039/d6pm00008h

January 1, 2026RSC PharmaceuticsOpen Access

Polymer-lipid hybrid nanoparticles co-encapsulating fucoxanthin and carbon dots for targeted anti-inflammatory therapy in Alzheimer´s disease

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Key Points

The aim is to develop nanoparticles that can deliver anti-inflammatory agents specifically for Alzheimer’s disease therapy.
Created polymer-lipid hybrid nanoparticles co-encapsulating fucoxanthin and carbon dots.
Targeted delivery mechanism focused on inflammatory pathways in Alzheimer’s disease.
Assessed therapeutic efficacy through in vitro and in vivo models.
Demonstrated effective targeting of inflammatory cells in Alzheimer’s models.
Showed reduction in amyloid-beta and Tau protein levels.
Indicated improved cognitive functions in treated models.

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Implication

Novel polymer-lipid hybrid nanoparticles target inflammation in Alzheimer's disease, indicating potential therapeutic avenues.

Abstract

Alzheimer´s disease (AD) is a long-term brain disorder characterized by the buildup of proteins like amyloid-beta (Aβ) and Tau. This disease process can start up to 20 years before symptoms...

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Silvestre-Martínez et al. (2026) studied this question.

synapsesocial.com/papers/69be37506e48c4981c676eba https://doi.org/10.1039/d6pm00008h

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Polymer-lipid hybrid nanoparticles co-encapsulating fucoxanthin and carbon dots for targeted anti-inflammatory therapy in Alzheimer´s disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Polymer-lipid hybrid nanoparticles co-encapsulating fucoxanthin and carbon dots for targeted anti-inflammatory therapy in Alzheimer´s disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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