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June 20, 2026Food & Function

Fucoxanthin enhances AMPK/mTOR-dependent autophagic flux and attenuates ferroptosis in Alzheimer’s disease models

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Authors

NLNayoung LeeKYKumju YounMMMinho Moon

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Overview

Randomized trial shows fucoxanthin reduces ferroptosis and enhances autophagy in Alzheimer’s models, suggesting potential therapeutic effects.

Key Points

  • The study aims to investigate the effects of fucoxanthin on autophagy and ferroptosis in Alzheimer’s disease models.
  • Utilized Alzheimer’s disease models to assess the impact of fucoxanthin on autophagic flux
  • Examined AMPK/mTOR signaling pathways involved in autophagy and neuroprotection
  • Conducted in vitro and in vivo experiments to support findings.
  • Fucoxanthin treatment significantly enhanced autophagic flux, indicated by increased LC3-II levels (p<0.01).
  • Marked reduction in neuronal ferroptosis was observed, with decreased lipid peroxidation levels (p<0.05).
  • Improved neuronal viability was demonstrated, correlating with enhanced AMPK/mTOR activity.

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/6a362fe6db0793dc1a537302https://doi.org/10.1039/d6fo01264g
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