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March 21, 2026International Journal of Molecular SciencesOpen Access

Membrane Vesicles from Lactobacillus acidophilus Promote Superior Cytokine Modulation and Antimicrobial Signaling Compared with Their Whole Cells in RAW 264.7 Macrophages

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Authors

CSCristal Dafne Lonngi SosaUniversidad de Cuautitlán IzcalliFDFrancisco DíazUniversidad de Cuautitlán IzcalliHÁHugo Ramírez ÁlvarezUniversidad de Cuautitlán Izcalli

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Implication

Research evaluates membrane vesicles' effectiveness in cytokine modulation and antimicrobial signaling in macrophages, suggesting novel therapeutic potentials.

Key Points

  • This research aims to assess whether membrane vesicles from Lactobacillus acidophilus are more effective than whole cells in modulating cytokine production and antimicrobial signaling in macrophages.
  • Used RAW 264.7 murine macrophage cell line for evaluation.
  • Compared the effects of membrane vesicles and whole cells from Lactobacillus acidophilus.
  • Assessed cytokine profiles and bactericidal activity against Escherichia coli.
  • Lactobacillus acidophilus membrane vesicles showed direct antibacterial effects against Escherichia coli.
  • Membrane vesicles induced a more balanced cytokine profile compared to whole cells.
  • The findings suggest potential applications for membrane vesicles in biotherapeutics.

Cite This Study

Sosa et al. (2026) studied this question.

synapsesocial.com/papers/69be37ce6e48c4981c677c33https://doi.org/10.3390/ijms27062764
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