Background. Metastatic cutaneous Crohn's Disease (MCD) is a rare cutaneous manifestation of Crohn’s Disease with significant morbidity, yet understanding is limited to case reports and small series. We aimed to identify risk factors associated with MCD development. Methods. This retrospective case-control study (1/2016–1/2024) included MCD patients confirmed using Delphi Panel criteria and controls with gastrointestinal Crohn's Disease, matched 1:2 by age and sex. Demographic factors, Crohn's Disease characteristics, medication history, surgical history, and extraintestinal manifestations were assessed via chart review. Odds ratios were calculated using conditional logistic regression. Results. Among 474 patients screened, 61 cases were matched with 122 controls. 77.0% were female with no significant differences in smoking history or BMI between groups. Factors significantly associated with increased MCD odds included perianal Crohn's disease (OR 6.79, 95% CI 1.47–31.36, p=0.014) and ostomy history (OR 72.65, 95% CI 3.50–1505.92, p=0.006) Conclusions. These findings represent an important step toward understanding MCD's pathogenesis and may inform future translational studies.
Baker et al. (2026) studied this question.