This analysis presents cases of medullated retinal nerve fibers, revealing related ophthalmic phenomena, indicating possible developmental mechanisms.
Twelve patients with medullated retinal nerve fibers are presented. The paper discusses the possible roles played by formation of the (1) ganglion cell axons and (2) lamina cribrosa in the development of medullated retinal nerve fibers. In addition to myopia and amblyopia, patients with medullated retinal nerve fibers may show unusual lens tilts, anterior chamber anomalies, unexpected field losses, and unusual direction of the optic nerve.
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T. David Williams (1986) studied this question.
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