Antenatal Exposure to Steroids and the Additional Prophylaxis Effect of Indomethacin to Prevent Intraventricular Hemorrhage

Following the publication of our multicenter randomized indomethacin intraventricular hemorrhage (IVH) prevention trial in Pediatrics,1 we received numerous queries concerning our protocol outcome variables. None was more intriguing to us, however, than the question of David Braun, MD, who asked what additional protective effect might be offered by the early administration of indomethacin to those infants who had been exposed to antenatal steroid administration and had no evidence of IVH at 6 hours postnatal age.