Key result
Indomethacin and ibuprofen for PDA show distinct adverse effect profiles including nephrotoxicity and NEC.
Why the study?
Do NSAIDs (indomethacin or ibuprofen) effectively and safely manage patent ductus arteriosus in preterm infants?
Systematic Review (n=15,657)
Do NSAIDs (indomethacin or ibuprofen) effectively and safely manage patent ductus arteriosus in preterm infants?
Both indomethacin and ibuprofen are utilized for PDA management in preterm infants, but ibuprofen may offer a more favorable safety profile regarding severe gastrointestinal and renal complications.
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Requires weighing distinct NSAID adverse profiles in PDA management; extends global trial data on preferences and safety.
Irmesi et al. (2014) conducted a systematic review in Patent Ductus Arteriosus (PDA) (n=15,657). NSAIDs (Indomethacin and Ibuprofen) was evaluated on Duct closure, surgical ligation and outcome. NSAIDs (indomethacin and ibuprofen) for PDA management across 89 trials (N=15,657) showed different regional preferences and distinct adverse effect profiles, including nephrotoxicity and NEC.
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