Why the study?
What is the safety and efficacy of oral medications for the management of patent ductus arteriosus in preterm infants?
Population
Preterm infants with patent ductus arteriosus (PDA)
Comparison
Oral medications vs Intravenous medications or alternative oral…
Design
Review
Authors
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May support oral ibuprofen preference in preterm PDA; leaves open need for prospective RCTs versus paracetamol.
What is the safety and efficacy of oral medications for the management of patent ductus arteriosus in preterm infants?
Oral ibuprofen is preferred for PDA closure in preterm infants due to superior efficacy over intravenous administration and better safety than indomethacin, with paracetamol emerging as a safer alternative.
Mehmet Yekta Öncel (2016) studied this question.
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