Key result
Acetaminophen is a promising alternative to indomethacin and ibuprofen for patent ductus arteriosus closure, offering comparable efficacy and a good short-term safety profile.
Why the study?
Controversy remains regarding if, when, and how to close persistent patent ductus arteriosus in premature infants.
Population
Premature infants with persistent patent ductus arteriosus (PDA)
Design
Review
Authors
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PDA closure decisions in extremely premature infants lack causal data; Level 5 evidence leaves open optimal timing, method, and benefit.
While COX inhibitors remain first-line for PDA closure, acetaminophen is emerging as a promising, lower-cost alternative with a favorable short-term safety profile.
John Ferguson (2018) conducted a review in Patent ductus arteriosus. Pharmacotherapy (indomethacin, ibuprofen, acetaminophen) was evaluated. Acetaminophen is a promising alternative to indomethacin and ibuprofen for patent ductus arteriosus closure, offering comparable efficacy and a good short-term safety profile.
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