Key result
Off-label oral paracetamol achieved ductal closure within 48 hours in 100% (5/5) of preterm infants with patent ductus arteriosus who failed or had contraindications to ibuprofen therapy.
Why the study?
Does oral paracetamol improve ductal closure in preterm infants with patent ductus arteriosus who failed or have contraindications to ibuprofen?
Population
5 preterm infants with large, hemodynamically significant patent ductus arteriosus who had either failed or…
Design
Case_series
Follow-up
48 hours
Authors
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May support paracetamol in ibuprofen-ineligible preterm PDA; hypothesis-generating and requires randomized confirmation before practice change.
Case Report (n=5)
Does oral paracetamol improve ductal closure in preterm infants with patent ductus arteriosus who failed or have contraindications to ibuprofen?
Oral paracetamol may serve as an effective and safe alternative for patent ductus arteriosus closure in preterm infants when standard cyclooxygenase inhibitors are contraindicated or ineffective.
Hammerman et al. (2011) conducted a case report in Patent ductus arteriosus (n=5). Oral paracetamol was evaluated on Ductal closure. Off-label oral paracetamol achieved ductal closure within 48 hours in 100% (5/5) of preterm infants with patent ductus arteriosus who failed or had contraindications to ibuprofen therapy.
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