Key result
A 6-day oral paracetamol course successfully closes a hemodynamically significant PDA in a preterm neonate.
Why the study?
Does oral paracetamol induce ductal closure in a late preterm neonate with hemodynamically significant PDA at 4 weeks postnatal age?
Case Report (n=1)
Does oral paracetamol induce ductal closure in a late preterm neonate with hemodynamically significant PDA at 4 weeks postnatal age?
Oral paracetamol may be an effective alternative for PDA closure in late preterm neonates at advanced postnatal age when COX inhibitors are contraindicated.
May warrant consideration when COX inhibitors are contraindicated; hypothesis-generating and should not yet change practice.
Pharmacological closure with cyclooxygenase (COX) inhibitors, such as indomethacin and ibuprofen, forms the first line of treatment for a patent ductus arteriosus (PDA) in preterm neonates. However, their efficacy decreases with increasing postnatal and postconceptual age. Paracetamol is gaining acceptance worldwide as an alternative drug for PDA closure and can be used when COX inhibitors are contraindicated, although its efficacy at advanced postnatal age is not well described. Here, we describe a late preterm neonate (36 weeks, 1150 g birth weight) with a hemodynamically significant PDA, where COX inhibitor therapy could not be initiated due to thrombocytopenia, and where oral paracetamol was started at 4 weeks postnatal age and caused ductal closure after a 6-day course.
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Chhina et al. (2016) conducted a case report in Patent ductus arteriosus (n=1). Oral paracetamol was evaluated on Ductal closure. A 6-day course of oral paracetamol successfully caused ductal closure in a late preterm neonate with a hemodynamically significant patent ductus arteriosus at 4 weeks postnatal age.
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