Key result
The effectiveness and safety of paracetamol for patent ductus arteriosus closure in extreme preterm neonates remain uncertain, highlighting the urgent need for prospective comparative trials.
Why the study?
Does paracetamol induce patent ductus arteriosus closure in extreme preterm neonates?
Population
Extreme preterm neonates with patent ductus arteriosus (PDA)
Comparison
Paracetamol vs Non-selective cyclo-oxygenase inhibitors
Design
Review
Authors
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Evidence insufficient to recommend paracetamol for PDA closure in extreme preterms; leaves open need for prospective RCTs.
Does paracetamol induce patent ductus arteriosus closure in extreme preterm neonates?
The use of paracetamol for PDA closure in extreme preterm neonates lacks robust evidence for efficacy and safety, highlighting an urgent need for prospective comparative trials.
Allegaert et al. (2013) conducted a review in Patent ductus arteriosus (PDA). Paracetamol vs. Non-selective cyclo-oxygenase inhibitors was evaluated. The effectiveness and safety of paracetamol for patent ductus arteriosus closure in extreme preterm neonates remain uncertain, highlighting the urgent need for prospective comparative trials.
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