Key result
Ibuprofen has a higher safety profile than indomethacin for managing patent ductus arteriosus in preterm infants, and paracetamol may be a safe alternative with low adverse events.
Why the study?
Does the choice of therapeutic drug (indomethacin, ibuprofen, or paracetamol) affect the safety profile in preterm infants with patent ductus arteriosus?
Population
Preterm infants with patent ductus arteriosus (PDA)
Design
Review
Authors
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Adverse effects of indomethacin/ibuprofen urge caution in preterm PDA; leaves open safer alternatives for prospective study.
Does the choice of therapeutic drug (indomethacin, ibuprofen, or paracetamol) affect the safety profile in preterm infants with patent ductus arteriosus?
Ibuprofen and paracetamol offer safer alternatives to indomethacin for the management of patent ductus arteriosus in preterm infants.
Öncel et al. (2015) conducted a review in Patent ductus arteriosus. Ibuprofen, indomethacin, and paracetamol was evaluated on Safety profile and adverse events. Ibuprofen has a higher safety profile than indomethacin for managing patent ductus arteriosus in preterm infants, and paracetamol may be a safe alternative with low adverse events.
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