Key result
Prolonged indomethacin therapy during pregnancy resulted in ductal constriction in 6.5%, oligohydramnios in 7.3%, and composite neonatal morbidity in 29% of cases.
Why the study?
Does prolonged indomethacin treatment during pregnancy cause oligohydramnios, constriction of the ductus arteriosus, or composite neonatal morbidity in pregnant women?
Population
n=124 pregnant women
Design
Cohort
Authors
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Supports fetal surveillance with prolonged indomethacin; leaves open causality and optimal use in prospective trials.
Cohort (n=124)
Does prolonged indomethacin treatment during pregnancy cause oligohydramnios, constriction of the ductus arteriosus, or composite neonatal morbidity in pregnant women?
Prolonged indomethacin therapy during pregnancy is rarely associated with ductal constriction and oligohydramnios, and these outcomes do not appear to be dose- or duration-dependent.
Savage et al. (2007) conducted a cohort in Pregnancy (n=124). Prolonged indomethacin therapy was evaluated on Oligohydramnios, constriction of the ductus arteriosus, and composite neonatal morbidity. Prolonged indomethacin therapy during pregnancy resulted in ductal constriction in 6.5%, oligohydramnios in 7.3%, and composite neonatal morbidity in 29% of cases.
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