Key result
Indomethacin exposure in fetuses resulted in normal echocardiograms in 74% of cases, with temporary tricuspid valve regurgitation (10%) and ductal constriction (6%) as the most common side effects.
Why the study?
What are the fetal echocardiographic findings and safety profile of indomethacin treatment in exposed fetuses?
Population
107 fetuses exposed to indomethacin (evaluated in 315 fetal echocardiogram studies)
Design
Cohort
Authors
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Indomethacin exposure was associated with mostly normal fetal echoes; leaves open whether routine monitoring improves outcomes in indicated tocolysis.
Observational (n=107)
What are the fetal echocardiographic findings and safety profile of indomethacin treatment in exposed fetuses?
Indomethacin treatment is relatively safe for the fetal heart, with tricuspid regurgitation and temporary ductal constriction being the most common side effects that do not necessarily contraindicate continued use.
Respondek et al. (1995) conducted an observational in Fetuses exposed to indomethacin (n=107). Indomethacin was evaluated on Fetal echocardiography findings. Indomethacin exposure in fetuses resulted in normal echocardiograms in 74% of cases, with temporary tricuspid valve regurgitation (10%) and ductal constriction (6%) as the most common side effects.
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