Key result
Prostaglandin synthetase inhibitors used for >72 hours in preterm labor were significantly associated with oligohydramnios compared to ritodrine or magnesium sulfate (50.7% vs 3.0%; P<0.001).
Why the study?
Do prostaglandin synthetase inhibitors increase the risk of oligohydramnios compared to ritodrine or magnesium sulphate in women with preterm labour?
Population
134 women with preterm labour (n=67 treatment, n=67 control)
Comparison
Prostaglandin synthetase inhibitors for greater… vs Ritodrine or magnesium sulphate
Design
Cohort
Authors
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May warrant amniotic fluid monitoring with prolonged use; leaves open causality and fetal outcomes pending randomized data.
Observational (n=134)
Do prostaglandin synthetase inhibitors increase the risk of oligohydramnios compared to ritodrine or magnesium sulphate in women with preterm labour?
Absolute Event Rate: 50.7% vs 3%
p-value: p=<0.001
The use of prostaglandin synthetase inhibitors for more than 72 hours in preterm labor is strongly associated with reversible oligohydramnios.
HENDRICKS et al. (1990) conducted an observational in Preterm labour (n=134). Prostaglandin synthetase inhibitors (indomethacin and ibuprofen) vs. Ritodrine or magnesium sulphate was evaluated on Ultrasound-recorded oligohydramnios (p=<0.001). Prostaglandin synthetase inhibitors used for >72 hours in preterm labor were significantly associated with oligohydramnios compared to ritodrine or magnesium sulfate (50.7% vs 3.0%; P<0.001).
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