What question did this study set out to answer?

The aim is to evaluate the effects of the herbal formula Kami Guibi-tang on brain function in amnestic mild cognitive impairment through neuroimaging.

March 25, 2026Brain Imaging and BehaviorOpen Access

Effects of the herbal prescription Kami Guibi-tang on brain function in amnestic mild cognitive impairment: a task-based and resting-state fMRI study

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Authors

DKDongjoo KimKyung Hee University Medical Center NKNa-yeon KimKyung Hee University MKMin-jae KwakKyung Hee University

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Implication

Randomized trial shows Kami Guibi-tang improves brain connectivity in individuals with amnestic mild cognitive impairment, suggesting cognitive benefits.

Key Points

The aim is to evaluate the effects of the herbal formula Kami Guibi-tang on brain function in amnestic mild cognitive impairment through neuroimaging.
Conducted a randomized, double-blind, placebo-controlled trial
Involved 84 participants with amnestic mild cognitive impairment
Participants received KGT or placebo for 24 weeks
Functional MRI assessed during memory tasks and resting states
Analyzed task-based and resting-state data for neural activation and connectivity
Placebo group had higher activation in memory-related regions at baseline
Post-intervention, activation differences between groups diminished
KGT group showed preserved or increased activation in frontal and cingulate regions
Resting-state connectivity increased between precuneus and posterior cingulate cortex after KGT administration
Results indicate KGT may positively influence memory-related brain processes

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69c37aa8b34aaaeb1a67c7e4 https://doi.org/10.1007/s11682-026-01138-6

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Implication

Randomized trial shows Kami Guibi-tang improves brain connectivity in individuals with amnestic mild cognitive impairment, suggesting cognitive benefits.

Effects of the herbal prescription Kami Guibi-tang on brain function in amnestic mild cognitive impairment: a task-based and resting-state fMRI study

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of the herbal prescription Kami Guibi-tang on brain function in amnestic mild cognitive impairment: a task-based and resting-state fMRI study

Discussion

Member takes

Implication

Key Points

Cite This Study

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