Key result
Intravascular large B-cell lymphoma induces neo-angiogenesis and nodular aggregates that mimic interstitial lung disease.
Why the study?
Intravascular large B-cell lymphoma is a rare entity that may mimic symptoms based on affected sites, and can present with pulmonary manifestations mimicking interstitial lung disease.
Intravascular large B-cell lymphoma can induce prominent neo-angiogenesis and mimic interstitial lung disease.
IVLBCL should enter the ILD differential; hypothesis-generating for neo-angiogenesis driving nodular aggregates.
Intravascular large B-cell lymphoma forms a rare entity that may mimic disease symptoms according to the affected sites. It is characterized by the presence of large atypical lymphoid B cells restricted to intravascular spaces, especially capillaries. We present a 65-year-old man who presented with a concurrent intravascular large B-cell lymphoma and Waldenström macroglobulinemia with prominent pulmonary symptoms masquerading as a hypersensitivity pneumonitis. A subsequent surgical lung biopsy illustrated peribronchial and interstitial nodular aggregates which consisted of numerous capillary structures filled with neoplastic B lymphocytes. This report hints toward potential induction of prominent neo-angiogenesis by intravascular large B-cell lymphoma, with development of intrapulmonary nodular aggregates mimicking interstitial lung disease.
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Lancelot et al. (2026) studied this question. Intravascular large B-cell lymphoma can induce prominent neo-angiogenesis and form intrapulmonary nodular aggregates that clinically mimic interstitial lung disease.
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