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March 25, 2026Applied Microbiology and BiotechnologyOpen Access

Evaluation of the biological activities of Bacillus cereus-synthesized titanium dioxide nanoparticles

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Authors

MAMarwa M. A. AbdallahREReham F. El-kasedGEGhadir S. El-Housseiny

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Overview

Evaluation demonstrates antimicrobial and antiviral properties of Bacillus cereus-synthesized titanium dioxide nanoparticles, highlighting their potential as novel therapies.

Key Points

  • The aim is to evaluate the biological activities of titanium dioxide nanoparticles synthesized using Bacillus cereus.
  • Green synthesis of TiO₂ NPs using Bacillus cereus cell-free supernatant and titanium tetra-isopropoxide.
  • Characterization through UV-Vis spectroscopy, TEM, DLS, EDX, XRD, and FTIR.
  • Assessment of antimicrobial activity with MIC determination and biofilm formation reduction.
  • Cytotoxicity testing on Caco-2 and Vero cell lines.
  • Evaluation of antiviral activity against HSV-1.
  • TiO₂ NPs showed antimicrobial activity with MIC values of 78 μg/mL (E. coli) to 2500 μg/mL (S. aureus).
  • Biofilm formation was reduced significantly by up to 65.72% for S. aureus at sub-MIC concentrations.
  • Cytotoxicity IC₅₀ values were 212.15 μg/mL for Caco-2 and 342.96 μg/mL for Vero cells.
  • Strong antiviral effect against HSV-1 with 74.74% inhibition at 60 µg/mL.

Cite This Study

Abdallah et al. (2026) studied this question.

synapsesocial.com/papers/69c37c33b34aaaeb1a67eef9https://doi.org/10.1007/s00253-026-13771-8
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Also Consider

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  1. 1Antimicrobial Activity and Confocal Microscopy of Bio-synthesized Titanium Nanoparticles from Prosopis cineraria Leaf Extract2025 · 2 citations
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  3. 3Biological Production of Titanium Dioxide Nanoparticles by a Combination Culture of Lactobacillus sp. and Bacillus sp. and Assessment of their Bioactivity2024
  4. 4Biogenic synthesis of TiO₂ nanoparticles from Crotalaria pallida and their antibacterial, antioxidant, anti-angiogenic, and anticancer activities2026
  5. 5Bacterial synthesis parameters and antibacterial mechanisms of titanium dioxide nanoparticles against multidrug resistant Gram-negative pathogens2026