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July 26, 2026Discover Applied SciencesOpen Access

Bacterial synthesis parameters and antibacterial mechanisms of titanium dioxide nanoparticles against multidrug resistant Gram-negative pathogens

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Authors

HDHanaw DarweshMAMuhammad AbdallaDGDennis Goevert

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Overview

Review evaluates synthesis factors and antimicrobial effects of titanium dioxide nanoparticles on multidrug-resistant Gram-negative bacteria, indicating future potential in combating resistance.

Key Points

  • This review aims to correlate bacterial synthesis parameters of titanium dioxide nanoparticles with their antimicrobial efficacy against multidrug-resistant Gram-negative pathogens.
  • Reviewed over 25 microbial species for titanium dioxide nanoparticles synthesis.
  • Analyzed how synthesis parameters like pH, temperature, and precursor types affect nanoparticle properties.
  • Evaluated antimicrobial mechanisms including reactive oxygen species generation and membrane disruption.
  • Identified key synthesis conditions that influence nanoparticle size and stability.
  • Highlighted generation of reactive oxygen species as a primary antibacterial mechanism.
  • Discussed challenges for clinical translation, including safety data.

Cite This Study

Darwesh et al. (2026) studied this question.

synapsesocial.com/papers/6a65a2e2d3aea3239cd76376https://doi.org/10.1007/s42452-026-09256-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Green-synthesized titanium dioxide nanoparticles: systematic review of antimicrobial efficacy and biocompatibility2026
  2. 2Schiff base-assisted catalytic fabrication of TiO <sub>2</sub> nanoparticles for antibacterial applications against multidrug-resistant strains2026
  3. 3Evaluation of the biological activities of Bacillus cereus-synthesized titanium dioxide nanoparticles2026 · 7 citations
  4. 4Green synthesis of Titanium dioxide nanoparticle using combination of plants and its antimicrobial study with their characterization2024 · 4 citations
  5. 5Biological Production of Titanium Dioxide Nanoparticles by a Combination Culture of Lactobacillus sp. and Bacillus sp. and Assessment of their Bioactivity2024