Inflammatory cytokines may contribute to diastolic heart failure by downregulating SERCA2 and decreasing diastolic calcium reuptake, suggesting a potential therapeutic target.
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TNF-α/IL-6 associations with diastolic HF via SERCA2 are hypothesis-generating; prospective studies needed before clinical consideration.
Through downregulation of SERCA2 gene expression, inflammatory cytokines may cause cardiac diastolic dysfunction by decreasing diastolic calcium reuptake. Our study may suggest novel therapeutic strategies for diastolic heart failure and critically ill patients by modulating inflammatory reactions.
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Wu et al. (2011) studied this question.
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