November 14, 2010
View Full PaperCardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure
Structured PICO
Does the addition of CRT to an ICD reduce rates of death and hospitalization for heart failure in patients with NYHA class II or III heart failure, a wide QRS complex, and left ventricular systolic dysfunction?
P
Population
Patients with NYHA class II or III heart failure, a wide QRS complex, and left ventricular systolic dysfunction
I
Intervention
Cardiac-resynchronization therapy (CRT) added to an implantable cardioverter-defibrillator (ICD)
C
Comparator
Implantable cardioverter-defibrillator (ICD) without CRT
O
Outcome
Rates of death and hospitalization for heart failurecomposite
Adding CRT to an ICD in patients with mild-to-moderate heart failure, wide QRS, and LV systolic dysfunction reduces death and HF hospitalization but increases adverse events.
Abstract
Among patients with NYHA class II or III heart failure, a wide QRS complex, and left ventricular systolic dysfunction, the addition of CRT to an ICD reduced rates of death and hospitalization for heart failure. This improvement was accompanied by more adverse events. (Funded by the Canadian Institutes of Health Research and Medtronic of Canada; ClinicalTrials.gov number, NCT00251251.).
Cite This Study
Tang et al. (Sun,) studied this question.