Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events

Arthur J. Moss; William J. Hall; David S. Cannom; Helmut Klein; Mary W. Brown; James P. Daubert; N.A. Mark Estes; Elyse Foster; Henry Greenberg; Steven L. Higgins; Marc A. Pfeffer; Scott D. Solomon; David J. Wilber; Wojciech Zaręba

doi:10.1056/nejmoa0906431

September 1, 2009New England Journal of Medicine

Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events

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Why the study?

Does CRT combined with ICD reduce heart-failure events in relatively asymptomatic patients with a low ejection fraction and wide QRS complex?

Key Points

To evaluate whether cardiac-resynchronization therapy combined with an implantable cardioverter-defibrillator reduces the risk of heart-failure events in mildly symptomatic patients with low ejection fraction and ventricular conduction delay.
Interventional randomized clinical trial (ClinicalTrials.gov identifier: NCT00180271).
Evaluated cardiac-resynchronization therapy (CRT) added to an implantable cardioverter-defibrillator (ICD) in relatively asymptomatic heart failure patients with reduced ejection fraction and wide QRS complex.
CRT combined with ICD significantly decreased the risk of heart-failure events compared to ICD therapy alone in the studied cohort.
Therapeutic benefit was evident in patients presenting with low ejection fraction and wide QRS duration despite mild or absent baseline symptoms.

Structured PICO

Does CRT combined with ICD reduce heart-failure events in relatively asymptomatic patients with a low ejection fraction and wide QRS complex?

P

Population

Relatively asymptomatic patients with a low ejection fraction and wide QRS complex

I

Intervention

Cardiac-Resynchronization Therapy (CRT) combined with Implantable Cardioverter-Defibrillator (ICD)

O

Outcome

Heart-failure events

Implication

CRT combined with an ICD decreases the risk of heart-failure events in relatively asymptomatic patients with low ejection fraction and wide QRS complex.

Abstract

CRT combined with ICD decreased the risk of heart-failure events in relatively asymptomatic patients with a low ejection fraction and wide QRS complex. (ClinicalTrials.gov number, NCT00180271.)

Discussion

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Cite This Study

Moss et al. (2009) studied this question.

synapsesocial.com/papers/69d575356e4506aa303c1451 https://doi.org/10.1056/nejmoa0906431

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Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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