Why the study?
Does cardiac resynchronization therapy improve exercise capacity, cardiac structure and function, and composite clinical response in patients with mildly symptomatic heart failure, a wide QRS complex, and an ICD indication?
Does cardiac resynchronization therapy improve exercise capacity, cardiac structure and function, and composite clinical response in patients with mildly symptomatic heart failure, a wide QRS complex, and an ICD indication?
In patients with mildly symptomatic heart failure, a wide QRS, and an ICD indication, CRT improves cardiac structure, function, and composite clinical response at 6 months, despite no significant change in exercise capacity.
CRT improves structure, function, and clinical response in mildly symptomatic HF with wide QRS and ICD; extends indications beyond exercise capacity endpoints.
In patients with mild heart failure symptoms on optimal medical therapy with a wide QRS complex and an ICD indication, CRT did not alter exercise capacity but did result in significant improvement in cardiac structure and function and composite clinical response over 6 months.
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Abraham et al. (2004) studied this question.
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