Effect of Cardiac Resynchronization Therapy on Left Ventricular Size and Function in Chronic Heart Failure
Key result
Cardiac resynchronization therapy reduced LV end-diastolic and end-systolic volumes, increased ejection fraction, and improved myocardial performance index at 6 months (P < 0.001).
Why the study?
Does cardiac resynchronization therapy improve left ventricular size and function in patients with moderate to severe systolic heart failure and ventricular dyssynchrony?
Population
Patients with moderate to severe systolic heart failure and ventricular dyssynchrony treated with optimal…
Comparison
Cardiac resynchronization therapy (CRT on) vs CRT off (control)
Design
RCT, Randomized to CRT on (n=172) or CRT off (n=151)
Follow-up
6 months
Authors
Discussion
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Implication
CRT improves LV structure/function in systolic HF with dyssynchrony; reinforces randomized evidence for reverse remodeling.
Structured PICO
Does cardiac resynchronization therapy improve left ventricular size and function in patients with moderate to severe systolic heart failure and ventricular dyssynchrony?
P
Population
Patients with moderate to severe systolic heart failure and ventricular dyssynchrony treated with optimal medical therapy
I
Intervention
Cardiac resynchronization therapy (CRT on)
C
Comparator
CRT off (control)
O
Outcome
Left ventricular size and function (including LV end-diastolic and end-systolic volumes, ejection fraction, LV mass, severity of mitral regurgitation, peak transmitral velocities, and myocardial performance index)surrogate
Cardiac resynchronization therapy induces significant reverse left ventricular remodeling and improves both systolic and diastolic function in patients with moderate-to-severe heart failure.
Cite This Study
Sutton et al. (2003) studied this question. Cardiac resynchronization therapy reduced LV end-diastolic and end-systolic volumes, increased ejection fraction, and improved myocardial performance index at 6 months (P < 0.001).