Key result
Cardiac resynchronization therapy in NYHA class I/II heart failure significantly decreased LV volume indexes (P<0.001) and increased LV ejection fraction (P<0.0001) at 12 months.
Why the study?
Does cardiac resynchronization therapy induce left ventricular reverse remodeling in patients with New York Heart Association class I/II heart failure?
RCT (n=610)
Does cardiac resynchronization therapy induce left ventricular reverse remodeling in patients with New York Heart Association class I/II heart failure?
p-value: p=<0.001
Cardiac resynchronization therapy induces significant structural and functional reverse remodeling at 1 year in patients with mild (NYHA I/II) heart failure, with the greatest benefit seen in nonischemic etiology.
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Supports CRT consideration in mild HF; extends reverse remodeling evidence to NYHA I/II.
Sutton et al. (2009) conducted an RCT in New York Heart Association Class I/II Heart Failure (n=610). Cardiac resynchronization therapy (CRT on) vs. Control (CRT off) was evaluated on Changes in LV end-diastolic and end-systolic volume indexes and LV ejection fraction (p=<0.001). Cardiac resynchronization therapy in NYHA class I/II heart failure significantly decreased LV volume indexes (P<0.001) and increased LV ejection fraction (P<0.0001) at 12 months.
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