Long-term impact of cardiac resynchronization therapy in mild heart failure: 5-year results from the REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction (REVERSE) study
Why the study?
Does cardiac resynchronization therapy produce sustained long-term clinical and echocardiographic benefits in patients with mild heart failure?
Population
419 patients with mild heart failure, QRS ≥120 ms, and left ventricular ejection fraction ≤40% initially…
Design
Cohort, randomized (initial phase), double-blind (initial phase)
Follow-up
mean 54.8 ± 13.0 months
Authors
Discussion
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Member takes
Implication
CRT associated with sustained LV reverse remodeling in mild HF; leaves open need for RCTs to confirm long-term benefits.
Structured PICO
Does cardiac resynchronization therapy produce sustained long-term clinical and echocardiographic benefits in patients with mild heart failure?
P
Population
419 patients with mild heart failure (NYHA Class I and II), QRS ≥120 ms, and left ventricular ejection fraction (LVEF) ≤40% initially assigned to CRT ON
I
Intervention
Cardiac resynchronization therapy (CRT ON) in addition to optimal medical therapy for up to 5 years
O
Outcome
Functional capacity, echocardiography, heart failure hospitalizations, mortality, and adverse events at 5 yearssurrogate
In patients with mild heart failure, cardiac resynchronization therapy produces sustained reverse left ventricular remodeling and clinical benefits over 5 years.
Cite This Study
Linde et al. (2013) studied this question.