August 1, 2018EuroIntervention

Left atrial appendage occlusion with the AMPLATZER Amulet device: one-year follow-up from the prospective global Amulet observational registry

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Why the study?

Does left atrial appendage occlusion with the AMPLATZER Amulet device prevent ischaemic stroke in patients at high risk of stroke and bleeding?

Structured PICO

Does left atrial appendage occlusion with the AMPLATZER Amulet device prevent ischaemic stroke in patients at high risk of stroke and bleeding?

Population

Patients at high risk of stroke and bleeding

Intervention

Left atrial appendage occlusion with the AMPLATZER Amulet device

Outcome

Annualised ischaemic stroke rate at one-year follow-uphard clinical

Left atrial appendage occlusion with the AMPLATZER Amulet device demonstrated a low annualised ischaemic stroke rate of 2.9% and high sealing rates at one year in a high-risk global registry.

Implication

Supports Amulet feasibility in high-risk patients; leaves open randomized efficacy versus anticoagulation.

Abstract

In the global prospective Amulet registry of patients at high risk of stroke and bleeding, the annualised ischaemic stroke rate was 2.9%. The LAA was sealed in 98.4% after one to three months and device-related thrombus was observed in 1.7% of cases with only a minority of all patients on anticoagulation treatment.