Why the study?
Does an implantable cardioverter defibrillator (ICD) reduce death compared to amiodarone in patients requiring secondary prevention?
Population
Patients requiring secondary prevention of arrhythmias/sudden cardiac death
Comparison
Implantable cardioverter defibrillator (ICD) vs Amiodarone
Design
Meta-analysis
Authors
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ICDs preferred to amiodarone for secondary prevention; reinforces RCT evidence of mortality benefit.
Does an implantable cardioverter defibrillator (ICD) reduce death compared to amiodarone in patients requiring secondary prevention?
In a meta-analysis of three secondary prevention trials, ICDs significantly reduced the relative risk of all-cause death by 28% and arrhythmic death by 50% compared to amiodarone.
Stuart J. Connolly (2000) studied this question.
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