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March 26, 2026Critical Care Medicine

778: Continuous vs Intermittent Renal Therapy in Critically Ill Cancer Patients With Aki

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Authors

SPSilvana Ribeiro PappRMRafael Hortêncio MeloPRPedro Bribean Rogovschi

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Overview

A retrospective cohort study compares outcomes of CRRT and IHD in critically ill cancer patients with AKI, suggesting different mortality and CKD risks.

Key Points

  • This study aims to compare the effectiveness of continuous renal replacement therapy (CRRT) and intermittent hemodialysis (IHD) in critically ill cancer patients with acute kidney injury (AKI).
  • Conducted as a retrospective cohort study using the TriNetX Global Collaborative Network.
  • Included adult patients aged 18-80 with active malignancy and AKI, matched by propensity score.
  • Compared 660 patients receiving CRRT against 660 patients receiving IHD.
  • Primary outcome assessed was 90-day all-cause mortality; secondary outcomes included advanced CKD and duration of mechanical ventilation.
  • CRRT showed higher 90-day mortality (55.5%) compared to IHD (42.4%), with RR 1.31 and HR 1.52, p < 0.001.
  • CRRT was linked to a lower rate of progression to advanced CKD (2.0%) versus IHD (9.3%), with RR 0.22 and HR 0.22, p < 0.001.
  • No significant differences were observed regarding the need for mechanical ventilation.

Cite This Study

Papp et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc98fdc3bde448917f69https://doi.org/10.1097/01.ccm.0001185108.24028.85
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical impact and safety of continuous renal replacement therapy in critically ill patients with solid tumors and acute kidney injury: a retrospective cohort analysis2025 · 2 citations
  2. 2Efficacy of Continuous Renal Replacement Therapy and Intermittent Hemodialysis in Patients with Renal Failure in Intensive Care Unit: A Systemic Review and Meta‐analysis2023 · 8 citations
  3. 3Epidemiology of Critically Ill Patients With Cirrhosis Undergoing Continuous Renal Replacement Therapy: A Contemporaneous Parallel Analysis of the HRS-HARMONY and CRRTnet Registries2026
  4. 4Initial renal replacement therapy (RRT) modality associates with 90-day postdischarge RRT dependence in critically ill AKI survivors2024 · 11 citations
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