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July 12, 2026CureusOpen Access

Outcomes Associated With Continuous Renal Replacement Therapy in Acute Respiratory Distress Syndrome With Acute Kidney Injury: A National Inpatient Sample Analysis

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Authors

AFAbdelhadi FaroujiSaint Michael's Medical CenterMUMuhammed UmerMAMu'ath Abdeen

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Overview

Retrospective cohort study evaluates CRRT outcomes in ARDS with AKI, suggesting substantial mortality risks.

Key Points

  • Evaluate outcomes associated with continuous renal replacement therapy in patients with acute respiratory distress syndrome and acute kidney injury.
  • Retrospective cohort study using HCUP-NIS data from 2016 to 2021
  • Identified adult hospitalizations with ARDS and AKI via ICD-10-CM codes
  • Performed multivariable logistic regression to analyze in-hospital outcomes related to CRRT use.
  • Of 485,035 hospitalizations, 26,995 (5.6%) received CRRT.
  • Unadjusted in-hospital mortality was 77.7% for CRRT patients versus 43.1% for non-CRRT patients (p < 0.001).
  • CRRT use was associated with higher odds of mortality (aOR 3.30; 95% CI 3.06-3.55) and complications such as mechanical ventilation and sepsis (all p < 0.001).

Cite This Study

Farouji et al. (2026) studied this question.

synapsesocial.com/papers/6a532e624f7abc118adecb0ehttps://doi.org/10.7759/cureus.112363
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A55-33 In-Hospital Outcomes of Acute Respiratory Distress Syndrome Patients Requiring Continuous Renal Replacement Therapy: A Nationwide Analysis (2016-2021)2026
  2. 2Outcomes Associated With Renal Replacement Therapy Use and Modality in Cardiogenic Shock Patients2025 · 3 citations
  3. 3The role of continuous renal replacement therapy in sepsis-associated acute kidney injury: a systematic review and meta-analysis2026
  4. 4Association between renal replacement therapy and in-hospital mortality in patients with severe acute kidney injury: a retrospective cohort study based on MIMIC-IV database2026 · 1 citations
  5. 5#916 Outcomes of renal replacement therapy in ICU adult patients with acute kidney injury: a retrospective cohort study2024