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March 26, 2026Nutrition ReviewsOpen Access

Nutraceuticals and the Microbiota–Gut–Brain Axis: A Pathway for Preventing Cognitive Decline

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Authors

ÁCÁngela Castillo-MoralCTCristina Toda-FerranMBMònica Bulló

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Overview

Narrative review evaluates nutraceuticals' effects on cognitive decline via the gut-brain pathway, suggesting preventive strategies.

Key Points

  • This review aims to assess the neuroprotective effects of nutraceuticals on cognitive decline related to aging.
  • Comprehensive literature search conducted in PubMed, Scopus, and Web of Science.
  • Focus on studies published between 2010 and 2025.
  • Evaluation of various nutraceuticals and their interaction with the microbiota-gut-brain axis.
  • Nutraceuticals showed neuroprotective properties via mechanisms like antioxidant and anti-inflammatory activities.
  • Gut microbiota significantly influences the bioavailability and effectiveness of these compounds.
  • Microbiome-targeted interventions demonstrated potential for improving cognitive function and reducing neuroinflammation.

Cite This Study

Castillo-Moral et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc98fdc3bde448917f88https://doi.org/10.1093/nutrit/nuag017
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Precision Nutrition and Gut–Brain Axis Modulation in the Prevention of Neurodegenerative Diseases2025 · 15 citations
  2. 2Plant-Derived Nutraceuticals in Mental Health and Brain Function: Mechanisms of Action and Therapeutic Potential2025
  3. 3Promoting cognitive health through the nexus of gut microbiota and dietary phytochemicals2025
  4. 4Natural Molecules for Brain Health and Resilience2026
  5. 5Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors2026