Long-term methotrexate therapy shows no pulmonary impairment in children with juvenile idiopathic arthritis, suggesting a reassuring profile.
In children with JIA, long-term treatment with MTX appears to be safe regarding the pulmonary outcome. Hepatic involvement was frequent but transient, occasionally requiring dose adjustment or discontinuation without long-term complications.
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Weßling et al. (2026) studied this question.
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