Key result
Rauwolfia serpentina extract mitigates cardiorenal damage in rats by reducing oxidative stress, inflammation, and fibrosis.
Why the study?
This study evaluated the protective effects of Rauwolfia serpentina root extract against isoprenaline-induced oxidative stress, fibrosis, and cardiac injury.
Does Rauwolfia serpentina root extract prevent oxidative stress, inflammation, and fibrosis in isoprenaline-administered rats?
Does Rauwolfia serpentina root extract prevent oxidative stress, inflammation, and fibrosis in isoprenaline-administered rats?
Rauwolfia serpentina root extract mitigates isoprenaline-induced cardiorenal damage in a rat model by reducing oxidative stress and inflammation, suggesting potential cardioprotective properties.
This study examined the protective effects of Rauwolfia serpentina root extract against isoprenaline (ISO)-induced oxidative stress, fibrosis, and cardiac injury in rats. ISO (50 mg/kg) was administered subcutaneously twice weekly. Biochemical markers, including uric acid, creatinine, CK-MB, MDA, NO, AOPP, and antioxidant enzymes, were evaluated, alongside histopathological analysis. ISO increased oxidative stress, inflammation, and cardiac damage, while R. serpentina treatment significantly reduced uric acid, creatinine, CK-MB, MDA, NO, AOPP, and myeloperoxidase levels, and restored antioxidant activity. Histology showed reduced fibrosis and inflammatory infiltration in treated rats. Gene expression analysis revealed downregulation of NF-κB, TNF-α, and IL-6, along with activation of the Nrf2-HO-1 pathway. Network pharmacology identified six key polyphenols in R. serpentina interacting with 141 cardiac hypertrophy-related proteins. Overall, R. serpentina mitigates ISO-induced cardiac and renal damage by reducing oxidative stress, inflammation, and fibrosis.
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Subhan et al. (2026) studied Isoprenaline-induced cardiac and renal injury (n=24). Rauwolfia serpentina root extract vs. Isoprenaline alone (50 mg/kg twice weekly) was evaluated on Biochemical markers of oxidative stress, inflammation, and cardiac injury (CK-MB, MDA, NO, AOPP) (p=<0.05). Rauwolfia serpentina root extract significantly mitigated isoprenaline-induced cardiac and renal damage in rats by reducing oxidative stress, inflammation, and fibrosis.
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