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March 26, 2026International Journal of Molecular SciencesOpen Access

Lysine Propionylation as a Metabolically Coupled PTM: Mechanisms, Functional Consequences, and Therapeutic Potentials

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Authors

ZLZhuofan LiuXWXiaoqiang WangZTE (China)LLLaurent LiKunming University of Science and Technology

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Implication

Proteomic analysis reveals the importance of lysine propionylation in gene regulation and metabolism, suggesting dietary modifications can influence its levels.

Key Points

  • The aim is to investigate lysine propionylation's role in linking metabolism to gene regulation.
  • Summarized recent advancements in propionyl-CoA sources.
  • Examined enzymatic mechanisms of lysine propionylation.
  • Analyzed functional consequences of lysine propionylation in various tissues.
  • Lysine propionylation occurs more frequently than previously recognized at specific lysine sites.
  • It exhibits context-dependent patterns and co-varies with other acylation types.
  • Propionyl-CoA availability can be influenced by diet and microbiome-derived fatty acids.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69c4cdb6fdc3bde44891a6e1https://doi.org/10.3390/ijms27072937
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pitfalls in histone propionylation during bottom‐up mass spectrometry analysis2015 · 45 citations
  2. 2Improved Mass Spectrometry–Based Methods Reveal Abundant Propionylation and Tissue-Specific Histone Propionylation Profiles2024 · 25 citations
  3. 3Histone acylation marks respond to metabolic perturbations and enable cellular adaptation2020 · 88 citations
  4. 4Small-sample learning reveals propionylation in determining global protein homeostasis2023 · 27 citations
  5. 5Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer2020 · 112 citations