Why the study?
Does exercise training and deconditioning affect platelet aggregation induced by alternating shear stress in men?
Does exercise training and deconditioning affect platelet aggregation induced by alternating shear stress in men?
Exercise training beneficially reduces shear stress-induced platelet aggregation and activation markers in men, but these protective cardiovascular effects are lost upon deconditioning.
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May warrant sustained training to retain lower shear-induced platelet aggregation; leaves open translation to clinical outcomes.
Exercise training suppresses the extent of ASIPA, probably by reducing vWF binding to platelets and P-selectin expression on platelets. However, deconditioning reverses the training effects. This investigation shows that exercise training decreases resting and severe exercise-promoted platelet aggregation induced by alternating shear stress (ASIPA); moreover, this effect is accompanied by reduced the von Willebrand factor binding and P-selectin expression on platelets. However, the effects of training on ASIPA are reversed to the pretraining state after deconditioning.
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Wang et al. (2004) studied this question.
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