Age-related sex differences in the outcomes of patients with hypertrophic cardiomyopathy

Fig 1. Sex differences in clinical outcomes. (A) Sex differences of event-free survival curves for clinical outcomes. (B) Independent association of sex with various outcomes. Multivariable adjustment was performed for age, body mass index, NYHA class, the SCD risk score, and left ventricular ejection fraction. *HF events = Admission for HF + Heart transplantation + Death due to HF + Progression to NYHA functional class III/IV. †Composite CV outcomes = CV death + SCD/SCD equivalent events + Admission for HF + Heart transplantation. CI, confidence interval; CV, cardiovascular; HF, heart failure; IR, incidence rate; NYHA, New York Heart Association; PY, person-years; SCD, sudden cardiac death.

Fig 2. Sex differences in clinical outcomes, stratified by age. (A) Below the age of 60, there was no significant difference in survival and composite cardiovascular outcome between the sexes under the age of 60, though there was a non-significant trend for higher incidence of the latter in women. (B) Over the age of 60, women showed worse survival and higher incidence of the composite cardiovascular outcomes compared to men.