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March 27, 2026Movement Disorders Clinical Practice0 citations

Exteroceptive Reflex Myoclonus Triggered by Distal Nerve Stimulation in Anti‐ GAD65 Stiff‐Person Syndrome

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JSJingwei SimTan Tock Seng HospitalCKChiun Khang KiewTan Tock Seng HospitalJVJoy VijayanTan Tock Seng Hospital

Key Points

  • This report aims to illustrate how distal nerve stimulation can trigger exteroceptive reflex myoclonus in a specific syndrome.
  • Video case report design
  • Patient with stiff-person syndrome
  • Observation of reflex responses to nerve stimulation
  • Distal nerve stimulation resulted in myoclonus in the patient
  • Myoclonus was characterized by specific reflexive movements
  • Findings highlight the potential for nerve stimulation to provoke unusual reflexes

Abstract

Ethical Compliance Statement: Institutional review board approval is not required for this work as it is a video case report. Written informed consent was obtained from the patient's guardian for publication of this case and images. All authors have read the Journal's position on issues involved in ethical publication and affirm that this work is consistent with those guidelines. Funding Sources and Conflict of Interest: The authors declare that there are no funding sources or conflict of interest relevant to this work. Financial Disclosures for the previous 12 months: T.Y. is supported by Roche for medical writing, and holds research grants from NMRC Singapore, Roche and AstraZeneca. He receives royalties from Numares AG, consulting fees from ASNA, AstraZeneca, Euroimmun AG, Merck, Novartis, Roche and Terumo BCT, and participates in Merck and AstraZeneca advisory boards. He holds two patents (USPTO 18043181, WIPO WO2022043706) and holds leadership roles in PACTRIMS, Multiple Sclerosis Society Singapore and Brain Bank Singapore. The rest of the authors have no financial disclosures from the last 36 months. Data supporting the findings of this study are available from the corresponding author upon reasonable request. Data S1. Supplementary Information. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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Cite This Study

Sim et al. (2026) studied this question.

synapsesocial.com/papers/69c620d515a0a509bde19804https://doi.org/10.1002/mdc3.70607
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