Key result
Aorticorenal ganglion ablation plus RDN enhances sympathetic denervation in pigs, with analogous human sites identified.
Why the study?
Does aorticorenal ganglion ablation combined with conventional renal denervation improve sympathetic denervation compared to conventional denervation alone in a porcine model?
Does aorticorenal ganglion ablation combined with conventional renal denervation improve sympathetic denervation compared to conventional denervation alone in a porcine model?
Absolute Event Rate: 76% vs 54%
Aorticorenal ganglion ablation combined with conventional renal denervation achieves greater efferent renal sympathetic denervation in a porcine model and demonstrates feasible pacing-induced hemodynamic responses in humans.
Combined aorticorenal ganglion ablation with RDN may warrant human investigation; extends preclinical evidence by identifying analogous functional sites.
BACKGROUND: Aorticorenal ganglia (ARG) serve as critical sympathetic relay centers for renal innervation, and their targeted ablation represents a promising alternative to conventional renal artery denervation by enabling precise disruption of renal sympathetic outflow through a transvenous approach. OBJECTIVE: To test feasibility and efficacy of sympathetic renal denervation (RDN) by targeting ARG using microwave (MW) catheter from inferior vena cava (IVC) in addition to conventional transarterial MW denervation and assess ARG localization in humans using pacing-induced physiological responses. METHODS: Pigs underwent sham ( n = 8), renal denervation (RDN; n = 7), or RDN plus ARG ablation (RDN + ARG; n = 7) using custom open-irrigated microwave catheter. Baseline ARG pacing caused renal vasoconstriction and raised mean arterial pressure (MAP). RDN and RDN + ARG groups received one ablation in each main renal artery (100-120 W, 360 s); RDN + ARG also had ARG ablation. After 4-5 weeks, ARG pacing was repeated before euthanasia. In humans ( n = 3), high-frequency pacing in IVC and renal veins identified ARG capture sites, guided by MRI and electroanatomical mapping. RESULTS: ARG ablation modified pacing responses acutely sustained at 4-5 weeks, with preservation of blood pressure response but significant loss of renal vasoconstriction. Compared to undenervated shams, RDN+ARG vs. RDN reduced viable nerve area by 76% vs. 54% and renal cortical norepinephrine by 51% vs. 15%. In humans, ARG stimulation increased MAP from 108.9 to 123.2 mmHg. CONCLUSIONS: ARG ablation, when combined with conventional RDN, achieves greater efferent renal sympathetic denervation in pigs. In humans, analogous sites were identified showing pacing-induced hemodynamic responses consistent with ARG.
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Balaji et al. (2026) studied this question. Renal denervation plus aorticorenal ganglia ablation (RDN + ARG) vs. Conventional renal denervation (RDN) or sham was evaluated on Reduction in viable nerve area compared to sham. Aorticorenal ganglia ablation combined with conventional renal denervation reduced viable nerve area by 76% vs 54% and renal cortical norepinephrine by 51% vs 15% compared to conventional RDN alone.
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