Ibuprofen Derived Supramolecular Topical Gel for Self Delivery Applications

A new small molecule–drug conjugate (SMDC) derived from the non-steroidal anti-inflammatory drug (NSAID) ibuprofen has been synthesized through an amidation reaction with the biogenic molecule 5-aminoisophthalic acid, with the objective of transforming the native nongelator ibuprofen into a sustainable supramolecular gelator for self-delivery applications. The resulting small molecule–drug conjugate exhibited efficient gelation in methyl salicylate, a widely used component in topical gel formulations. Comprehensive characterization, including tabletop and dynamic rheological measurements, confirmed the mechanical stability of the gel, while HR-TEM imaging revealed an entangled fibrous network characteristic of supramolecular self-assembly. Overall, the strategic modification of ibuprofen into a small molecule–drug conjugate demonstrates a promising pathway for developing NSAID-based supramolecular gels for controlled topical drug-delivery systems.