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January 1, 2026Journal of Immunology ResearchOpen Access

Analysis of the Mediating Effect of Vitamin D via the TGF‐β1/Treg Pathway in the Pathogenesis of Childhood Primary Immune Thrombocytopenia

Peiling Li Mengru Chen Zhihang Wang Rui Fan Jia Guo Bao Liu Zhiyin Wang Yanyan Ma Dongju Zhao Shujun Li

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Key Points

The study investigates how vitamin D affects immune thrombocytopenia in children via the TGF-β1/Treg pathway.
Analyzed the levels of vitamin D, TGF-β1, and Treg cells in children with newly diagnosed immune thrombocytopenia.
Evaluated the correlation between these elements to assess their mediating effects.
Dysregulation of vitamin D, TGF-β1, and Treg cells is observed in affected children.
TGF-β1 is identified as a key mediator in the regulation of immune thrombocytopenia by vitamin D.

Implication

Analysis reveals vitamin D's role in immune thrombocytopenia through TGF-β1/Treg pathways, suggesting new therapeutic targets.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69c7723a8bbfbc51511e2912 https://doi.org/10.1155/jimr/4001873

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Platelet-derived TGF-β1 and Treg maintenance in a murine model of ITPOriginal Research · 2026 · 1 citations
2The cytokines (IFN-γ, IL-2, IL-4, IL-10, IL-17) and Treg cytokine (TGF-β1) levels in adults with immune thrombocytopeniaOriginal Research · 2014
3The Role of Interferon γ in the Diagnosis and Prognosis of Childhood Primary Immune Thrombocytopenia2024
4MicroRNA-cytokine interplay and treg dysregulation in pediatric immune thrombocytopenia: implications for disease chronicityCross-Sectional Study · 2026
5Clinical characteristics and decreased CD4+CD25+Foxp3+ regulatory T cells and IL-35 in pediatric immune thrombocytopenia in a single centerOriginal Research · 2026

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