This review analyzes 5-fluorouracil's effects on cancer cells, suggesting improvements for efficacy and resistance prevention.
5-Fluorouracil is a uracil analog that has been used for over 65 years to treat a wide variety of neoplasms and diseases. It does so by disrupting normal nucleotide synthesis of both DNA and RNA, leading to tumor cell death [1]. This review aims to discuss the history of this medication, its mechanisms of action, and address the need for further research into increasing efficacy and preventing tumor resistance.
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Hayden Dudek (2025) studied this question.
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