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November 11, 2024JAMA80 citations

Calcific Aortic Stenosis

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COCatherine M OttoDNDavid E. NewbyGHGraham S. Hillis

Structured PICO

Does SAVR or TAVI reduce mortality in older adults with symptomatic severe calcific aortic stenosis?

P
Population
Older adults with symptomatic severe calcific aortic stenosis
I
Intervention
Surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI)
O
Outcome
Mortalityhard clinical

SAVR and TAVI are life-saving interventions for symptomatic severe calcific aortic stenosis, reducing mortality to match age-matched controls.

Abstract

Calcific AS is a common chronic progressive condition among older adults and is diagnosed via echocardiography. Symptomatic patients with severe AS have a mortality rate of up to 50% after 1 year, but treatment with SAVR or TAVI reduces mortality to that of age-matched control patients. The type and timing of valve replacement should be built on evidence-based guidelines, shared decision-making, and involvement of a multidisciplinary heart valve team.

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Cite This Study

Otto et al. (2024) studied this question.

synapsesocial.com/papers/69c7f3881b47d466e5369c9fhttps://doi.org/10.1001/jama.2024.16477
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnosis and Management of Valvular Aortic Stenosis2014 · 106 citations
  2. 2Aortic Stenosis in the Older Population2013
  3. 3Aortic stenosis: medical and surgical management2005 · 69 citations
  4. 4Degenerative calcific aortic stenosis: a natural history2012 · 106 citations
  5. 5Aortic Stenosis: Changing Disease Concepts2015 · 45 citations