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March 29, 2026Cell ReportsOpen Access

Innate imprinting of transcriptional trajectories governs respiratory TRM fate and persistence

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Authors

HPHongtae ParkBKBrock Kingstad-BakkeTCThomas Cleven

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Overview

Demonstrates how innate inflammation shapes T cell memory, implying new strategies for mucosal immunity.

Key Points

  • The research aims to understand how different innate signals influence the fate of respiratory T cells.
  • Used precision adjuvant activity with different pattern recognition receptor agonists.
  • Investigated the effects of Toll-like receptor and stimulator of interferon genes on CD8 T cell trajectories.
  • Analyzed differentiation of T<sub>RM</sub> precursors during influenza and vaccination.
  • Toll-like receptor signaling promoted long-lived type 3 T<sub>RM</sub> cells through specific transcriptional programs.
  • Stimulator of interferon genes increased attrition-prone type 1 T<sub>RM</sub> cells via a distinct signaling pathway.
  • Identified two divergent progenitor populations responsible for tissue and systemic memory T cell responses.

Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/69c8c115de0f0f753b39ba0ehttps://doi.org/10.1016/j.celrep.2026.117197
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antigen-mediated NF-κB signaling: key to establishing lung resident T cell memory during influenza infection 28432025
  2. 2Discovery of Exhausted-like Lung Tissue-Resident Memory T Cells as Key Mediators of Protective Immunity 22579442026
  3. 3Cellular and molecular heterogeneity of lung resident T memory cells in protective immunity 28192025
  4. 4The role of the T-cell receptor (TCR) in the generation of lung CD4+ tissue-resident memory T cells (TRM) following influenza infection 23075952026
  5. 5Translational values of tissue‐resident memory T cells in chronic inflammation and cancer2025