What question did this study set out to answer?

To investigate the changes in molecular aberrations in AML patients undergoing treatment with oral decitabine/cedazuridine.

March 29, 2026CancersOpen Access

Serial Determinations of Molecular Aberrations in Patients with Acute Myeloid Leukemia During Treatment with Oral Decitabine/Cedazuridine

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Authors

KGKlaus GeisslerSigmund Freud Privatuniversität Wien GBGabriele BenetkaHorse Hospital MPMaximilian Prinz-WohlgenanntHorse Hospital

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Implication

Observational study reports changes in molecular aberrations during decitabine therapy, suggesting implications for treatment response in AML patients.

Key Points

To investigate the changes in molecular aberrations in AML patients undergoing treatment with oral decitabine/cedazuridine.
Monitored molecular markers during treatment in a subset of five AML patients.
Assessed changes in the mutational landscape and blast cell counts throughout the therapy.
Evaluated overall survival based on treatment response.
No significant reduction in mutated AML clones for four out of five patients.
One patient achieved complete remission with a decrease in variant allele frequency (VAF) of mutated clones.
Two patients experienced significant decreases in blast cells without changes in their molecular profiles.
Patients with complete or partial response had significantly longer overall survival compared to non-responders.
80% of patients had potentially targetable mutations at diagnosis, including IDH2, NPM1, and FLT3.

Cite This Study

Geissler et al. (2026) studied this question.

synapsesocial.com/papers/69c8c25dde0f0f753b39ca03 https://doi.org/10.3390/cancers18071093

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Implication

Observational study reports changes in molecular aberrations during decitabine therapy, suggesting implications for treatment response in AML patients.

Serial Determinations of Molecular Aberrations in Patients with Acute Myeloid Leukemia During Treatment with Oral Decitabine/Cedazuridine

Discussion

Member takes

Implication

Key Points

Cite This Study

Serial Determinations of Molecular Aberrations in Patients with Acute Myeloid Leukemia During Treatment with Oral Decitabine/Cedazuridine

Discussion

Member takes

Implication

Key Points

Cite This Study

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